Alkylation Reactions of Azodicarboxylate Esters with 4-Alkyl-1,4-Dihydropyridines under Catalyst-Free Conditions

Kazunari Nakajima*, Yulin Zhang, Yoshiaki Nishibayashi*

*School of Engineering, The University of Tokyo, Bunkyo-ku, Tokyo 113-8656, Japan, Email: nakajimasys.t.u-tokyo.ac.jp, ynishibasys.t.u-tokyo.ac.jp

K. Nakajima, Y. Zhang, Y. Nishibayashi, Org. Lett., 2019, 21, 4642-4645.

DOI: 10.1021/acs.orglett.9b01537

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Abstract

Reactions of 4-alkyl-1,4-dihydropyridines as alkylation reagents with di-tert-butyl azodicarboxylate provide alkyl amine derivatives under heating conditions in the absence of catalysts and additives.

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proposed mechanism

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Key Words

Hydrazine Derivatives

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ID: J54-Y2019