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CO2/Photoredox-Cocatalyzed Tandem Oxidative Cyclization of α-Bromo Ketones and Amines To Construct Substituted Oxazoles

Xiaowei Zhang, Yonghui He, Jing Li, Rui Wang, Lijun Gu*, Ganpeng Li*

*Yunnan Minzu University, Kunming, Yunnan 650500, China, Email: gulijun2005126.com, ganpeng_lisina.com.cn

X. Zhang, Y. He, J. Li, R. Wang, L. Gu, G. Li, J. Org. Chem., 2019, 84, 8225-8231.

DOI: 10.1021/acs.joc.9b00283


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Abstract

A CO2/photoredox-cocatalyzed tandem oxidative cyclization of α-bromo ketones and amines enables the preparation of substituted oxazoles. The absence of both transition-metal catalysts and peroxides makes this method more sustainable.

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Key Words

oxazoles, photochemistry


ID: J42-Y2019