Radical α,β-Dehydrogenation of Saturated Amides via α-Oxidation with TEMPO under Transition Metal-Free Conditions
Mei-Mei Wang, Guo-Hui Sui, Xian-Chao Cui, Hui Wang, Jian-Ping Qu*, Yan-Biao Kang*
*Nanjing Tech University, Nanjing 211816; University of Science and Technology of China, Hefei, Anhui 230026, China,
Email: ias_jpqu
njtech.edu.cn, ybkangustc.edu.cn
M.-M. Wang, G.-H. Sui, X.-C. Cui, H. Wang, J.-P. Qu, Y.-B. Kang, J. Org. Chem., 2019, 84, 8267-8274.
DOI: 10.1021/acs.joc.9b00872
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Abstract
A transition metal-free radical α,β-dehydrogenation of saturated amides under mild conditions even provides α,β-unsaturated Weinreb amides and acrylamides. Mechanistic studies confirm the radical nature of this transformation.
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Key Words
ID: J42-Y2019
