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Manganese-Catalyzed Ring-Opening Coupling Reactions of Cyclopropanols with Enones

Yong-Hui Zhang, Wen-Wei Zhang, Ze-Yu Zhang, Kai Zhao*, Teck-Peng Loh*

*Nanjing Tech University, Nanjing 211816, China; Nanyang Technological University, Singapore 637371, Singapore, Email: ias_kzhaonjtech.edu.cn, teckpengntu.edu.sg

Y.-H. Zhang W.-W. Zhang, Z.-Y. Zhang, K. Zhao, T.-P. Loh, Org. Lett., 2019, 21, 5101-5105.

DOI: 10.1021/acs.orglett.9b01703 (free Supporting Information)


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Abstract

A manganese-catalyzed ring-opening coupling reaction of cyclopropanols with enones enables the facile and efficient preparation of a wide array of synthetically important 1,6-diketones bearing manifold functional groups in good yield. These reaction features broad substrate scope, environmentally benign conditions, inexpensive catalyst, and operational simplicity.

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Key Words

carbonyl compounds


ID: J54-Y2019