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Chiral Bidentate Boryl Ligand Enabled Iridium-Catalyzed Enantioselective C(sp3)-H Borylation of Cyclopropanes

Yongjia Shi, Qian Gao, Senmiao Xu*

*Suzhou Research Institute, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China, Email: senmiaoxulicp.cas.cn

Y. Shi, Q. Gao, S. Xu, J. Am. Chem. Soc., 2019, 141, 10599-10604.

DOI: 10.1021/jacs.9b04549 (free Supporting Information)


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Abstract

An Ir-catalyzed enantioselective C(sp3)-H borylation of cyclopropanecarboxamides using a chiral bidentate boryl ligand provides β-borylated products with good to excellent enantioselectivities. The borylated products can be used as versatile precursors.

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Key Words

borylation, cyclopropanes


ID: J48-Y2019