LiCl-Accelerated Multimetallic Cross-Coupling of Aryl Chlorides with Aryl Triflates
Liangbin Huang, Laura K. G. Ackerman, Kai Kang, Astrid M. Parsons, Daniel J. Weix*
*University of Wisconsin−Madison, Madison, Wisconsin 53706, United States, Email: dweixwisc.edu
L. Huang, L. K. G. Ackerman, K. Kang, A. M. Parsons, D. J. Weix, J. Am. Chem. Soc., 2019, 141, 10978-10983.
DOI: 1010.1021/jacs.9b05461 (free Supporting Information)
The selectivity challenge associated with cross-coupling of aryl chlorides as inert electrophiles with aryl triflates as reactive ones is overcome using a multimetallic strategy with the appropriate choice of additive. LiCl is essential for effective cross-coupling by accelerating the reduction of Ni(II) to Ni(0) and counteracting autoinhibition of reduction at Zn(0) by Zn(II) salts.
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