Chemoselective, Regioselective, and Enantioselective Allylations of NH2OH under Iridium Catalysis
Jiteng Chen, Qingchun Liang, Xiaoming Zhao*
*School of Chemical Technology and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, People's Republic of China, Email: xmzhao08mail.tongji.edu.cn
J. Chen, Q. Liang, X. Zhao, Org. Lett., 2019, 21, 5383-5386.
DOI: 10.1021/acs.orglett.9b01357 (free Supporting Information)
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The utilization of unprotected NH2OH, which is not only an oxygen nucleophile but also a nitrogen nucleophile, in iridium-catalyzed allylic substitution provides N-(1-allyl)hydroxylamines in good to high yields with high level of chemoselectivities, regioselectivities, and enantioselectivities under mild, carefully adjusted reaction conditions.
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