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Cobalt-Catalyzed Regio- and Enantioselective Allylic Amination

Samir Ghorai, Sahadev Shrihari Chirke, Wen-Bin Xu, Jia-Feng Chen, Changkun Li*

*School of Chemistry and Chemical Engineering Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China, Email: chklisjtu.edu.cn

S. Ghorai, S. S. Chirke, W.-B. Xu, J.-F. Chen, C. Li, J. Am. Chem. Soc., 2019, 141, 11430-11434.

DOI: 10.1021/jacs.9b06035


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Abstract

A cobalt-catalyzed highly branched- and enantioselective allylic amination of racemic branched allylic carbonates bearing alkyl groups with both aromatic and aliphatic amines provides allylic amines in high yields with exclusively branched selectivity and excellent enantioselectivities under mild reaction conditions.

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Key Words

allylic amines, aryl amines


ID: J48-Y2019