Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy
Zhi-Tao He, John F. Hartwig*
*Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, United States,
Email: jhartwig
berkeley.edu
Z.-T. He, J. F. Hartwig, J. Am. Chem. Soc., 2019, 141, 11749-11753.
DOI: 10.1021/jacs.9b03291
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Abstract
A traceless protecting strategy enables a palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both coupling processes occur with various carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups.
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Key Words
ID: J48-Y2019
