Iridium-Catalyzed Alkene-Selective Transfer Hydrogenation with 1,4-Dioxane as Hydrogen Donor
Deliang Zhang, Tomohiro Iwai*, Masaya Sawamura*
*Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060-0810, Japan, Email: iwai-tsci.hokudai.ac.jp, sawamurasci.hokudai.ac.jp
D. Zhang, T. Iwai, M. Sawamura, Org. Lett., 2019, 21, 5867-5872.
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The use of 1,2-bis(dicyclohexylphosphino)ethane (DCyPE) as ligand enabled an iridium-catalyzed transfer hydrogenation of alkenes using 1,4-dioxane as a hydrogen donor. A polystyrene-cross-linking bisphosphine PS-DPPBz produced a reusable heterogeneous catalyst. The reaction tolerates other potentially reducible functional groups such as carbonyl, nitro, cyano, and imino groups.
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reduction of alkenes, 1,4-reduction of α,β-unsaturated compounds, 1,4-dioxane