Stereospecific Synthesis of E-Alkenes through Anti-Markovnikov Hydroalkylation of Terminal Alkynes
Avijit Hazra, Jason Chen, Gojko Lalic*
*University of Washington, Seattle, Washington 98103, United States,
Email: lalic
chem.washington.edu
A. Hazra, J. Chen, G. Lalic, J. Am. Chem. Soc., 2019, 141, 12464-12469.
DOI: 10.1021/jacs.9b04800
Abstract
The cooperative action of copper and nickel catalysts enables a stereospecific hydroalkylation of terminal alkynes with alkyl iodides to provide E-alkenes with excellent anti-Markovnikov selectivity. The reaction can be accomplished in the presence of esters, nitriles, aryl bromides, ethers, alkyl chlorides, anilines, and a wide range of nitrogen-containing heteroaromatic compounds.
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Key Words
ID: J48-Y2019
