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Iron(0)-Mediated Reformatsky Reaction for the Synthesis of β-Hydroxyl Carbonyl Compounds

Xuan-Yu Liu, Xiang-Rui Li, Chen Zhang, Xue-Qiang Chu, Weidong Rao, Teck-Peng Loh*, Zhi-Liang Shen*

*Nanyang Technological University, Singapore 637371, Singapore; Nanjing Tech University, Nanjing 211816, China Email:,

X.-Y. Liu, X.-R. Li, C. Zhang X.-Q. Chu, W. Rao, T.-P. Loh, Z.-L. Shen, Org. Lett., 2019, 21, 5873-5878.

DOI: 10.1021/acs.orglett.9b01999 (free Supporting Information)

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An efficient, economical, and practical Reformatsky reaction of α-halo esters with carbonyl compounds is mediated by cheap iron(0) powder. The reactions proceeded effectively in the presence of a catalytic amount of iodine to afford synthetically useful β-hydroxyl carbonyl compounds in good yields.

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Key Words

Reformatsky Reaction, Iron

ID: J54-Y2019