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α-Methylation of 2-Arylacetonitrile by a Trimethylamine-Borane/CO2 System

Xiaowei Zhang, Sheng Wang, Chanjuan Xi*

*MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: cjxitsinghua.edu.cn

X. Zhang, S. Wang, C. Xi, J. Org. Chem., 2019, 84, 9744-9749.

DOI: 10.1021/acs.joc.9b01587 (free Supporting Information)


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Abstract

The use of trimethylamine-borane facilitates a six-electron reduction of CO2 for a highly selective monomethylation of 2-arylacetonitrile derivatives. Various 2-arylpropionitriles were obtained in good yields.

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Key Words

nitriles, trimethylamine borane


ID: J42-Y2019