α-Methylation of 2-Arylacetonitrile by a Trimethylamine-Borane/CO2 System
Xiaowei Zhang, Sheng Wang, Chanjuan Xi*
*MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: cjxitsinghua.edu.cn
X. Zhang, S. Wang, C. Xi, J. Org. Chem., 2019, 84, 9744-9749.
DOI: 10.1021/acs.joc.9b01587
see article for more reactions
Abstract
The use of trimethylamine-borane facilitates a six-electron reduction of CO2 for a highly selective monomethylation of 2-arylacetonitrile derivatives. Various 2-arylpropionitriles were obtained in good yields.
see article for more examples
Key Words
nitriles, trimethylamine borane
ID: J42-Y2019