Organic Chemistry Portal

Abstracts

Search:

Direct Synthesis of Vicinal Tricarbonyl Amides by Coupling of α-Oxo Acid Chlorides with Carbamoylsilanes

Yuling Han, Yuping Li, Shenghua Han, Pengpeng Zhang, Jianxin Chen*

*College of Chemistry and Engineering, Shanxi Datong University, Datong 037009, P. R. China, Email: chenjxsxnu.edu.cn

Y. Han, Y. Li, S. Han, P. Zhang, J. Chen, Synthesis, 2019, 51, 2977-2983.

DOI: 10.1055/s-0037-1611778


see article for more reactions

Abstract

The cross-coupling reaction of α-oxo acid chlorides with carbamoylsilanes provides vicinal tricarbonyl amides in good yields under mild conditions. The reaction of carbamoylsilanes with oxalyl chloride is accompanied by decarbonylation to give vicinal tricarbonyl amides.

see article for more examples



Key Words

α-oxo acid chlorides, carbamoylsilanes, vicinal tricarbonyl compounds, aminocarbonylation, α-keto amides, synthetic methods


ID: J66-Y2019