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Direct Synthesis of Vicinal Tricarbonyl Amides by Coupling of α-Oxo Acid Chlorides with Carbamoylsilanes

Yuling Han, Yuping Li, Shenghua Han, Pengpeng Zhang, Jianxin Chen*

*College of Chemistry and Engineering, Shanxi Datong University, Datong 037009, P. R. China, Email:

Y. Han, Y. Li, S. Han, P. Zhang, J. Chen, Synthesis, 2019, 51, 2977-2983.

DOI: 10.1055/s-0037-1611778

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The cross-coupling reaction of α-oxo acid chlorides with carbamoylsilanes provides vicinal tricarbonyl amides in good yields under mild conditions. The reaction of carbamoylsilanes with oxalyl chloride is accompanied by decarbonylation to give vicinal tricarbonyl amides.

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Key Words

α-oxo acid chlorides, carbamoylsilanes, vicinal tricarbonyl compounds, aminocarbonylation, α-keto amides, synthetic methods

ID: J66-Y2019