Asymmetric Multifunctional Modular Organocatalysis: One-Pot Direct Strategy to Enantiopure α,β-Disubstituted γ-Butyrolactones
Pratibha Mahto, Nirmal K. Rana, Khyati Shukla, Braja G. Das, Harshit Joshi, Vinod K. Singh*
*Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur - 208 016, UP, India,
Email: vinodks
iitk.ac.in
P. Mahto, N. K. Rana, K. Shukla, B. G. Das, H. Joshi, V. K. Singh, Org. Lett., 2019, 21, 5962-5966.
DOI: 10.1021/acs.orglett.9b02094
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Abstract
A multifunctional modular organocatalysis enables a simple and efficient approach to enantioenriched α,β-disubstituted γ-butyrolactones via a one-pot sequential Michael-hemiacetalization-oxidation reaction. The catalytic process offers good substrate compatibility, and the products can be transformed to synthetically useful molecules.
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proposed mechanism
Key Words
lactones, organocatalysis, PCC
ID: J54-Y2019
