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Pd-Catalyzed Highly Chemo- and Regioselective Hydrocarboxylation of Terminal Alkyl Olefins with Formic Acid

Wenlong Ren, Jianxiao Chu, Fei Sun, Yian Shi*

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States, Email: yian.shicolostate.edu

W. Ren, J. Chu, F. Sun, Y. Shi, Org. Lett., 2019, 21, 5967-5970.

DOI: 10.1021/acs.orglett.9b02101


Abstract

An efficient Pd-catalyzed hydrocarboxylation of alkenes with HCOOH provides a broad range of linear carboxylic acids bearing various functional groups with excellent chemo- and regioselectivities under mild reaction conditions. The reaction process is operationally simple and requires no handling of toxic CO.

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A Ligand-Directed Catalytic Regioselective Hydrocarboxylation of Aryl Olefins with Pd and Formic Acid

W. Liu, W. Ren, J. Li, Y. Shi, W. Chang, Y. Shi, Org. Lett., 2017, 19, 1748-1751.

An Effective Pd-Catalyzed Regioselective Hydroformylation of Olefins with Formic Acid

W. Ren, W. Chang, J. Dai, Y. Shi, J. Li, Y. Shi, J. Am. Chem. Soc., 2016, 138, 14864-14867.


Key Words

hydrocarboxylation


ID: J54-Y2019