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Asymmetric Hydroarylation of Enones via Nickel-Catalyzed 5-Endo-Trig Cyclization

Xurong Qin, Marcus Wen Yao Lee, Jianrong Steve Zhou*

*School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Nanshan District, Shenzhen 518055, China, Email: jrzhoupku.edu.cn

X. Qin, M. W. Y. Lee, J. S. Zhou, Org. Lett., 2019, 21, 5990-5994.

DOI: 10.1021/acs.orglett.9b02130 (free Supporting Information)


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Abstract

A nickel-catalyzed reductive cyclization of broad range of enones affords indanones in high enantiomeric induction. The versatility of this method is demonstrated in several short stereoselective syntheses of medically valuable (R)-tolterodine, (+)-indatraline, and (+)-multisianthol.

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Key Words

indanones, manganese


ID: J54-Y2019