Synthesis of α,β-Disubstituted Acrylates via Galat Reaction

Tania Xavier, Sylvie Condon*, Christophe Pichon, Erwan Le Gall, Marc Presset*

*Electrochimie et Synthèse Organique, Université Paris Est, ICMPE, (UMR 7182), CNRS, UPEC, 2-8 rue Henri Dunant, F-94320 Thiais, France, Email: condonicmpe.cnrs.fr, presseticmpe.cnrs.fr

T. Xavier, S. Condon, C. Pichon, E. Le Gall, M. Presset, Org. Lett., 2019, 21, 6135-6139.

DOI: 10.1021/acs.orglett.9b02291

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Abstract

Morpholine efficiently catalyzes Galat reactions between aldehydes and substituted malonic acids half oxyester in refluxing toluene to provide diverse α,β-disubstituted acrylates in to good yields. This method constitutes an attractive alternative to existing methods in terms of scope and eco-compatibility.

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Key Words

unsaturated esters, organocatalysis

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ID: J54-Y2019