A Regioselective Approach to C3-Aroylcoumarins via Cobalt-Catalyzed­ C(sp²)-H Activation Carbonylation of Coumarins

Rahim Pashazadeh*, Saideh Rajai-Daryasarei, Siyavash Mirzaei, Mehdi Soheilizad, Samira Ansari, Meisam Shabanian

*SOHA Pharmaceutical Company, PO BOX 31999-98461, Karaj, Iran, Email: pashazadeh.rahimyahoo.com

R. Pashazadeh, S. Rajai-Daryasarei, S. Mirzaei, M. Soheilizad, S. Ansari, M. Shabanian, Synthesis, 2019, 51, 3014-3020.

DOI: 10.1055/s-0037-1610702

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Abstract

Upon activation with manganese powder, a cobalt-catalyzed C-H bond activation of coumarins with aryl halides or pseudohalides in the presence of carbon monoxide provides various 3-aroylcoumarin derivatives under mild conditions.

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Key Words

cobalt-catalyzed, manganese, C-H activation, carbon monoxide, carbonylation, coumarins, 3-aroylcoumarins, multicomponent reactions

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ID: J66-Y2019