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Synthesis of Flavanones via Palladium(II)-Catalyzed One-Pot β-Arylation of Chromanones with Arylboronic Acids

Hyung-Seok Yoo, Seung Hwan Son, Yang Yil Cho, Soo Jin Lee, Hyu Jeong Jang, Young Min Kim, Dong Hwan Kim, Nam Yong Kim, Boyoung Y. Park, Yong Sup Lee, Nam-Jung Kim*

*College of Pharmacy, Department of Life and Nanopharmaceutical Sciences, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea, Email: kimnjkhu.ac.kr

H.-S. Yoo, S.-H. Son, Y. Y. Cho, S. J. Lee, H. J. Jang, Y. M. Kim, D. H. Kim, N. Y. Kim, B. Y. Park, Y. S. Lee, N.-J. Kim, J. Org. Chem., 2019, 84, 10012-10023.

DOI: 10.1021/acs.joc.9b01162 (free Supporting Information)



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Abstract

A broad range of flavanones were synthesized in very good yields via a palladium-catalyzed dehydrogenation of chromanones followed by arylation with arylboronic acids. This reaction provides a route to interesting natural products such as naringenin trimethyl ether.

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Key Words

flavanones, oxygen


ID: J42-Y2019