Catalyst-Free Regioselective N² Arylation of 1,2,3-Triazoles Using Diaryl Iodonium Salts

Sahar Roshandel, Maiko J. Lunn, Golam Rasul, Daniel Sylvinson Muthiah Ravinson, Suresh C. Suri, G. K. Surya Prakash*

*Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, United States, Email: gprakashusc.edu

S. Roshandel, M. J. Lunn, G. Rasul, D. S. M. Ravinson, S. C. Suri, G. K. S. Prakash, Org. Lett., 2019, 21, 6255-6258.

DOI: 10.1021/acs.orglett.9b02140

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Abstract

A catalyst-free and regioselective N arylation enables the synthesis of N²-aryl-1,2,3-triazoles in very good yields. This scalable postmodification protocol is effective for a wide range of substrates.

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Key Words

2H-1,2,3-triazoles, N-arylation

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ID: J54-Y2019