Organic Chemistry Portal



Iron-Catalyzed Regioselective Decarboxylative Alkylation of Coumarins and Chromones with Alkyl Diacyl Peroxides

Can Jin*, Xun Zhang, Bin Sun*, Zhiyang Yan, Tengwei Xu

*Zhejiang University of Technology, Hangzhou 310014, P. R. of China, Email:,

C. Jin, X. Zhang, B. Sun, Z. Yan, T. Xu, Synlett, 2019, 30, 1585-1591.

DOI: 10.1055/s-0037-1611864 (free Supporting Information)

see article for more reactions


A facile iron-catalyzed decarboxylative radical coupling of alkyl diacyl peroxides with coumarins or chromones provides α-alkylated coumarins and β-alkylated chromones containing a wide scope of functional groups in good yields. The reaction proceeds smoothly without adding any ligand or additive and offers high regioselectivity, readily available starting materials, and operational simplicity.

see article for more examples

Visible-Light-Induced Regioselective Alkylation of Coumarins via Decarboxylative Coupling with N-Hydroxyphthalimide Esters

C. Jin, Z. Yan, B. Sun, J. Yang, Org. Lett., 2019, 21, 2064-2068.

Key Words

coumarins, chromones, C-C bond, iron-catalyzed, decarboxylation

ID: J72-Y2019