Rhenium-Catalyzed Phthalide Synthesis from Benzamides and Aldehydes via C-H Bond Activation

Bing Jia, Yunhui Yang, Xiqing Jin, Guoliang Mao*, Congyang Wang*

*Northeast Petroleum University, Daqing 163318; Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Email: maoguoliangnepu.edu.cn; wangcyiccas.ac.cn

B. Jia, Y. Yang, X. Jin, G. Mao, C. Wang, Org. Lett., 2019, 21, 6259-6263.

DOI: 10.1021/acs.orglett.9b02142

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Abstract

A rhenium-catalyzed C-H activation enables a [4 + 1] annulation of a broad range of benzamides with aldehydes to provide phthalides.

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Key Words

phthalides

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ID: J54-Y2019