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Hypervalent Iodine(III)-Mediated Tosyloxylation of 4-Hydroxycoumarins

Bowen Xu, Yiping Gao, Jianwei Han*, Zejing Xing, Sihan Zhao, Ziyang Zhang, Runlin Ren, Limin Wang*

*School of Chemistry and Molecular Engineering, East China University of Science & Technology, 130 Meilong Road, Shanghai 200237, China, Email:,

B. Xu, Y. Gao, J. Han, Z. Xing, S. Zhao, Z. Zhang, R. Ren, L. Wang, J. Org. Chem., 2019, 84, 10136-10144.

DOI: 10.1021/acs.joc.9b01323

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The use of Koser's reagent enables an efficient synthesis of 3-tosyloxy-4-hydroxycoumarins under mild conditions. The reaction tolerates various functional groups.

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Key Words

coumarins, Koser's reagent

ID: J42-Y2019