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Iron-Catalyzed Anti-Markovnikov Hydroamination and Hydroamidation of Allylic Alcohols

Wei Ma, Xiaohui Zhang, Juan Fan, Yuxuan Liu, Weijun Tang, Dong Xue, Chaoqun Li, Jianliang Xiao*, Chao Wang*

*School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an, 710062, China, Email:,

W. Ma, X. Zhang, J. Fan, Y. Liu, W. Tang, D. Xue, C. Li, J. Xiao, C. Wang, J. Am. Chem. Soc., 2019, 141, 13506-13515.

DOI: 10.1021/jacs.9b05221


An iron-catalyzed hydroamination and hydroamidation of allylic alcohols provides γ-amino and γ-amido alcohols, respectively. The catalytic system, consisting of a pincer Fe-PNP complex, a weak base, and a nonpolar solvent, offers exclusive anti-Markovnikov selectivity, broad substrate scope, and good functional group tolerance.

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ID: J48-Y2019