Metal-Ligand Cooperative Approach To Achieve Dehydrogenative Functionalization of Alcohols to Quinolines and Quinazolin-4(3H)-ones under Mild Aerobic Conditions
Siuli Das, Suman Sinha, Deepannita Samanta, Rakesh Mondal, Gargi Chakraborty, Paula Brandaġ, Nanda D. Paul*
*Department of Chemistry, Indian Institute of Engineering Science and Technology, Shibpur, Botanic Garden, Howrah 711103, West Bengal, India, Email: ndpaul2014chem.iiests.ac.in
S. Das, S. Sinha, D. Samanta, R. Mondal, G. Chakraborty, P. Brandaġ, N. D. Paul, J. Org. Chem., 2019, 84, 10160-10171.
DOI: 10.1021/acs.joc.9b01343 (free Supporting Information)
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A simple metal-ligand cooperative approach enables dehydrogenative functionalization of benzylic alcohols to various substituted quinolines and quinazolin-4(3H)-ones in good yields under relatively mild reaction conditions using simple and easy-to-prepare air-stable Cu(II) complexes featuring redox-active azo-aromatic scaffolds.
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