Chemoselective Mono- and Difluorination of 1,3-Dicarbonyl Compounds

Lin Tang*, Zhen Yang, Jingchao Jiao, Ying Cui, Guodong Zou, Qiuju Zhou, Yuqiang Zhou*, Weihao Rao, Xiantao Ma*

*College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, P. R. China, Email: lintangxynu.edu.cn, yqzhouxynu.edu.cn, xiantaoma126.com

L. Tang, Z. Yang, J. Jiao, Y. Cui, G. Zou, Q. Zhou, Y. Zhou, W. Rao, X. Ma, J. Org. Chem., 2019, 84, 10449-10458.

DOI: 10.1021/acs.joc.9b01808

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Abstract

By altering the amount of Selectfluor, a highly selective mono- and difluorination of 1,3-dicarbonyl compounds provides various 2-fluoro- and 2,2-difluoro-1,3-dicarbonyl compounds in very good yields. This practical and convenient fluorination can be performed in aqueous media without any catalyst and base.

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Key Words

fluoroketones, fluoroamides, selectfluor

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ID: J42-Y2019