Harnessing Autoxidation of Aldehydes: In Situ Iodoarene Catalyzed Synthesis of Substituted 1,3,4-Oxadiazole, in the Presence of Molecular Oxygen
Jyoti Chauhan, Mahesh K Ravva, Subhabrata Sen*
*Department of Chemistry, School of Natural Sciences, Shiv Nadar University, Dadri, Chithera, Gautambudh Nagar, Uttar Pradesh 201314, India,
Email: subhabrata.sen
snu.edu.in
J. Chauhan, M. K. Ravva, S. Sen, Org. Lett., 2019, 21, 6562-6565.
DOI: 10.1021/acs.orglett.9b02542
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Abstract
The auto-oxidation of isobutyraldehyde in the presence of molecular oxygen generates acyloxy radicals, which in situ afford a hypervalent iodine compound with p-anisolyl iodide. A hypervalent iodine mediated reaction of N'-arylidene acetohydrazides provides substituted 1,3,4-oxadiazoles in good yields in parallel.
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Key Words
1,3,4-Oxadiazoles, Oxygen, Hypervalent Iodine Compounds
ID: J54-Y2019
