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Oxyacylation of Iodoalkynes: Gold(I)-Catalyzed Expeditious Access to Benzofurans

Paula Fernández-Canelas, Eduardo Rubio, José M. González*

*Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo, Spain, Email:

P. Fernández-Canelas, E. Rubio, J. M. González, Org. Lett., 2019, 21, 6566-6569.

DOI: 10.1021/acs.orglett.9b02551 (free Supporting Information)

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A gold(I) complex catalyzes the cycloisomerization of a broad range of 2-(iodoethynyl)aryl esters to give 3-iodo-2-acyl benzofurans via a [1,2]-iodine shift, a C-O ring-closure step, and a C-C bond-formation that installs the ketone functionality into the new ring.

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Key Words


ID: J54-Y2019