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KOtBu-Promoted Transition-Metal-Free Transamidation of Primary and Tertiary Amides with Amines

Tridev Ghosh, Snehasish Jana, Jyotirmayee Dash*

*School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A and 2B Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, India, Email:

T. Ghosh, S. Jana, J. Dash, Org. Lett., 2019, 21, 6690-6694.

DOI: 10.1021/acs.orglett.9b02306

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The use of potassium tert-butoxide enables transamidation of primary and tertiary amides with a range of aryl, heteroaryl, and aliphatic amines at room temperature under transition-metal-free conditions to provide secondary amides in high yields. Moreover, the reaction of cyclopropyl amine with tertiary amides delivers enamides.

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Key Words


ID: J54-Y2019