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Nickel-Catalyzed Decarbonylative Cyanation of Acyl Chlorides

Zhenhua Wang, Xiu Wang, Yasuyuki Ura, Yasushi Nishihara*

*Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan, Email: ynishihaokayama-u.ac.jp

Z. Wang, X. Wang, Y. Ura, Y. Nishihara, Org. Lett., 2019, 21, 6690-6694.

DOI: 10.1021/acs.orglett.9b02398 (free Supporting Information)



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Abstract

A Ni-catalyzed decarbonylative cyanation of acyl chlorides with trimethylsilyl cyanide is applicable to the synthesis of an array of nitrile compounds bearing a wide range of functional groups under neutral conditions.


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Key Words

cyanation, nitriles


ID: J54-Y2019