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Ni-Catalyzed Enantioselective Intermolecular Hydroamination of Branched 1,3-Dienes Using Primary Aliphatic Amines

Gaël Tran, Wen Shao, Clément Mazet*

*Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneva, Switzerland, Email:

G. Tran, W. Shao, C. Mazet, J. Am. Chem. Soc., 2019, 141, 14814-14822.

DOI: 10.1021/jacs.9b07253

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A Ni-catalyzed intermolecular enantioselective hydroamination of branched 1,3-dienes with linear or α-branched aliphatic primary amines or secondary amines provides valuable chiral allylic amines. The reaction is broadly applicable and highly regio-, chemo-, and enantioselective.

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Key Words

allylic amines

ID: J48-Y2019