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Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand

Kouichi Tanaka, Takashi Miki, Kunihiko Murata, Ayumi Yamaguchi, Yoshihito Kayaki, Shigeki Kuwata*, Takao Ikariya, Masahito Watanabe*

*Tokyo Institute of Technology, 2-12-1-E4-1 O-okayama, Meguro-ku, Tokyo 152-8552; Kanto Chemical Co., Inc., 7-1, Inari 1-chome, Soka-city, Saitama 340-0003, Japan, Email: skuwataapc.titech.ac.jp, watanabe-masahitogms.kanto.co.jp

K. Tanaka, T. Miki, K. Murata, A. Yamaguchi, Y. Kayaki, S. Kuwata, T. Ikariya, M. Watanabe, J. Org. Chem., 2019, 84, 10962-10977.

DOI: 10.1021/acs.joc.9b01565 (free Supporting Information)


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Abstract

Cp*Ir complexes bearing a 2-picolinamide moiety effectively catalyze a direct reductive amination of ketones to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source.

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Key Words

reductive amination, primary amines, formate salts


ID: J42-Y2019