Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand
Kouichi Tanaka, Takashi Miki, Kunihiko Murata, Ayumi Yamaguchi, Yoshihito Kayaki, Shigeki Kuwata*, Takao Ikariya, Masahito Watanabe*
*Tokyo Institute of Technology, 2-12-1-E4-1 O-okayama, Meguro-ku, Tokyo 152-8552; Kanto Chemical Co., Inc., 7-1, Inari 1-chome, Soka-city, Saitama 340-0003, Japan,
Email: skuwata
apc.titech.ac.jp, watanabe-masahitogms.kanto.co.jp
K. Tanaka, T. Miki, K. Murata, A. Yamaguchi, Y. Kayaki, S. Kuwata, T. Ikariya, M. Watanabe, J. Org. Chem., 2019, 84, 10962-10977.
DOI: 10.1021/acs.joc.9b01565
see article for more reactions
Abstract
Cp*Ir complexes bearing a 2-picolinamide moiety effectively catalyze a direct reductive amination of ketones to give primary amines under transfer hydrogenation conditions using ammonium formate as both the nitrogen and hydrogen source.
see article for more examples
Key Words
reductive amination, primary amines, formate salts
ID: J42-Y2019
