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Organoselenium-Catalyzed Aza-Wacker Reactions: Efficient Access to Isoquinolinium Imides and an Isoquinoline N-Oxide

Huimin Li, Lihao Liao, Xiaodan Zhao*

*Institute of Organic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China, Email:

H. Li, L. Liao, X. Zhao, Synlett, 2019, 30, 1688-1692.

DOI: 10.1055/s-0039-1690103

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An efficient organoselenium-catalyzed aza-Wacker reaction of olefinic hydrazones and oximes provides isoquinolinium imides and an isoquinoline N-oxides. This transformation involves a direct intramolecular C-H amination.

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Key Words

organoselenium catalysis, NFSI, aza-Wacker reaction, C-H amination, hydrazones, isoquinolines

ID: J72-Y2019