Rh(III)-Catalyzed Coupling of N-Chloroimines with α-Diazo-α-phosphonoacetates for the Synthesis of 2H-Isoindoles
Bing Qi, Lei Li, Qi Wang, Wenjing Zhang, Lili Fang, Jin Zhu*
*School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China,
Email: jinz
nju.edu.cn
B. Qi, L. Li, Q. Wang, W. Zhang, L. Fang, J. Zhu, Org. Lett., 2019, 21, 6860-6863.
DOI: 10.1021/acs.orglett.9b02501
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Abstract
A Rh(III)-catalyzed coupling of N-chloroimines with α-diazo-α-phosphonoacetates enables an efficient dechlorinative/dephosphonative access to 2H-isoindoles. In addition, a Ni(II)-catalyzed deesterification enables the complete elimination of reactivity-assisting groups.
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Key Words
ID: J54-Y2019
