Direct C3 Alkoxylation of Quinoxalin-2(1H)-ones with Alcohols via Cross-Dehydrogenative Coupling under Catalyst-Free Conditions

Qiming Yang, Xulin Han, Jiquan Zhao, Hong-Yu Zhang*, Yuecheng Zhang*

*School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, P. R. China, Email: zhanghyhebut.edu.cn, yczhanghebut.edu.cn

Q. Yang, X. Han, J. Zhao, H.-Y. Zhang, Y. Zhang, J. Org. Chem., 2019, 84, 11417-11424.

DOI: 10.1021/acs.joc.9b01181

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Abstract

A facile and effective alkoxylation of quinoxalin-2(1H)-ones with primary or secondary alcohols via cross-dehydrogenative coupling under catalyst-free conditions provides 3-alkoxylquinoxalin-2(1H)-ones in very good yields in the presence of PhI(OTFA)₂ as oxidant.

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Key Words

Quinoxalinones, PIFA

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ID: J42-Y2019