Stereodivergent Coupling of 1,3-Dienes with Aldimine Esters Enabled by Synergistic Pd and Cu Catalysis
Qinglong Zhang, Huimin Yu, Lulu Shen, Tianhua Tang, Dongfang Dong, Weiwei Chai, Weiwei Zi*
*State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China,
Email: zi
nankai.edu.cn
Q. Zhang, H. Yu, L. Shen, T. Tang, D. Dong, W. Chai, W. Zi, J. Am. Chem. Soc., 2019, 141, 14554-14559.
DOI: 10.1021/jacs.9b07600
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Abstract
A synergistic Pd and Cu catalysis enables stereodivergent coupling reactions between 1,3-dienes and aldimine esters with wide substrate scope and good functional group tolerance. By using different enantiomers of the two metal catalysts, all four stereoisomers of the coupling products could be accessed with high diastereo- and enantioselectivity.
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Key Words
ID: J48-Y2019
