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TEMPO-Me: An Electrochemically Activated Methylating Agent

Philip L. Norcott, Chelsey L. Hammill, Benjamin B. Noble, Johnathon C. Robertson, Angus Olding, Alex C. Bissember*, Michelle L. Coote*

*University of Tasmania, Hobart, Tasmania 7001; Australian National University, Canberra, Australian Capital Territory 2601, Australia Email:,

P. L. Norcott, C. L. Hammill, B. B. Noble, J. C. Robertson, A. Olding, A. C. Bissembler, M. L. Coote, J. Am. Chem. Soc., 2019, 141, 15450-15455.

DOI: 10.1021/jacs.9b08634

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The one-electron electrochemical oxidation of TEMPO-Me produces a powerful electrophilic methylating agent, that can be used for a methylation of aromatic acids.

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Key Words

alkylation, electrochemistry

ID: J48-Y2019