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Ir-Catalyzed Regiocontrolled Allylic Amination of Di-/Trienyl Allylic Alcohols with Secondary Amines

Shengbiao Tang, Ziyong Li, Ying Shao, Jiangtao Sun*

*Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, 1 Gehu Road, 213164, Changzhou, China, Email:

S. Tang, Z. Li, Y. Shao, J. Sun, Org. Lett., 2019, 21, 7228-7232.

DOI: 10.1021/acs.orglett.9b02435

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An unprecedented regio-controllable Ir-catalyzed allylic amination of unactivated dienyl and trienyl allylic alcohols provides C1-, C3-, and C5-/C7-amination products. Key to this protocol is the use of secondary amines as the amination reagents and scandium triflate as additive.

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Key Words

allylic amines

ID: J54-Y2019