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Cobalt-Catalyzed Allylation of Amides with Styrenes Using DMSO as Both the Solvent and the α-Methylene Source

Xu Zhang, Zhi Zhou, Huiying Xu, Xuefeng Xu, Xiyong Yu*, Wei Yi*

*School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China, Email:,

X. Zhang, Z. Zhou, H. Xu, X. Xu, X. Yu, W. Yi, Org. Lett., 2019, 21, 7248-7253.

DOI: 10.1021/acs.orglett.9b02462

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A cobalt-catalyzed allylation of amides with styrenes, in which DMSO was used as both the solvent and the α-methylene source, provides privileged allylic amines in high yields, and selectivity for the (E)-isomer of the linear product.

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proposed mechanism

Key Words

amides, allylic amines, potassium peroxydisulfate, multicomponent reactions

ID: J54-Y2019