Copper-Catalyzed Aldol Reaction of Vinyl Azides with Trifluoromethyl Ketones

Zhenhua Liu, Zhihai Zhang, Guangyu Zhu, Yiqin Zhou, Lin Yang, Wen Gao*, Lili Tong, Bo Tang*

*College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan 250014, P. R. China, Email: gaowensdnu.edu.cn, tangbsdnu.edu.cn

Z. Liu, Z. Zhang, G. Zhu, Y. Zhou, L. Yang, W. Gao, L. Tong, B. Tang, Org. Lett., 2019, 21, 7324-7328.

DOI: 10.1021/acs.orglett.9b02616

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Abstract

An efficient copper-catalyzed aldol reaction of readily available vinyl azides with trifluoromethyl ketones provides trifluoromethylated compounds under mild conditions in very good yield.

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Key Words

β-hydroxy ketones, trifluromethyl carbinols

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ID: J54-Y2019