Deaminative Arylation of Amino Acid-derived Pyridinium Salts
Megan E. Hoerrner, Kristen M. Baker, Corey H. Basch, Earl M. Bampo and Mary P. Watson*
*Department of Chemistry & Biochemistry, University of Delaware, Newark, Delaware 19716, United States,
Email: mpwatson
udel.edu
M. E. Hoerrner, K. M. Baker, C. H. Basch, E. M. Bampo, M. P. Watson, Org. Lett., 2019, 21, 7356-7360.
DOI: 10.1021/acs.orglett.9b02643
see article for more reactions
Abstract
A Suzuki-Miyaura cross-coupling of α-pyridinium esters and arylboroxines provides α-aryl esters and amides. Combined with formation of the pyridinium salts, this method enables an efficient transformation of amino acid derivatives under mild conditions and broad functional group tolerance.
see article for more examples
Key Words
ID: J54-Y2019
