Formation of Acetals and Ketals from Carbonyl Compounds: A New and Highly Efficient Method Inspired by Cationic Palladium
Enoch A. Mensah*, Shawn D. Green, Jesse West, Tyler Kindoll, Brenda Lazaro-Martinez
*School of Natural Sciences, Indiana University Southeast, 4201 Grant Line Road, New Albany, IN 47150, USA, Email: mensaheius.edu
E. A. Mensah, S. D. Green, J. West, T. Kindoll, B. Lazaro-Martinez, Synlett, 2019, 30, 1810-1814.
DOI: 10.1055/s-0039-1690497 (free Supporting Information)
see article for more reactions
Pd catalysis enables a highly efficient and simple method for masking a broad range of carbonyl groups as acetals and ketals in excellent yields. This protocol is mild and proceeds with a very low catalyst loading at ambient temperature.
see article for more examples