Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates
Mahipal Yadav and Ramanarayanan Krishnamurthy*
*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Email: rkrishnascripps.edu
M. Yadav, R. Krishnamurthy, Org. Lett., 2019, 21, 7400-7404.
see article for more reactions
Bis(dimethylamino)phosphorodiamidate enables an efficient one-pot cyclophosphorylation of vicinal cis-diol moieties of biologically interesting polyols without the need for protecting group chemistry. The reaction is amenable to large-scale reactions.
see article for more examples