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Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates

Mahipal Yadav and Ramanarayanan Krishnamurthy*

*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Email:

M. Yadav, R. Krishnamurthy, Org. Lett., 2019, 21, 7400-7404.

DOI: 10.1021/acs.orglett.9b02694

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Bis(dimethylamino)phosphorodiamidate enables an efficient one-pot cyclophosphorylation of vicinal cis-diol moieties of biologically interesting polyols without the need for protecting group chemistry. The reaction is amenable to large-scale reactions.

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Key Words


ID: J54-Y2019