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Selective Ketone Formations via Cobalt-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols

Bedraj Pandey, Shi Xu and Keying Ding*

*Department of Chemistry, Middle Tennessee State University, Murfreesboro, Tennessee 37132, United States, Email:

B. Pandey, S. Xu, K. Ding, Org. Lett., 2019, 21, 7400-7404.

DOI: 10.1021/acs.orglett.9b02727

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An environmentally benign and atom economical cobalt-catalyzed β-alkylation of secondary alcohols with primary alcohols provides ketones via acceptorless dehydrogenative coupling. The reaction produces water and hydrogen gas as the only byproducts.

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ID: J54-Y2019