N-Heterocyclic Carbene-Catalyzed Radical Relay Enabling Vicinal Alkylacylation of Alkenes
Takuya Ishii, Kenji Ota, Kazunori Nagao* and Hirohisa Ohmiya*
*Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan,
Email: nkazunori
p.kanazawa-u.ac.jp, ohmiyap.kanazawa-u.ac.jp
T. Ishii, K. Ota, K. Nagao, H. Ohmiya, J. Am. Chem. Soc., 2019, 141, 14073-14077.
DOI: 10.1021/jacs.9b07194
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Abstract
A N-heterocyclic carbene-catalyzed radical relay enables the vicinal alkylacylation of styrenes, acrylates and acrylonitrile with complete regioselectivity using aldehydes and tertiary alkyl carboxylic acid-derived redox-active esters to produce functionalized ketone derivatives.
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Key Words
acylation, alkylation, multicomponent reactions, organocatalysis
ID: J48-Y2019
