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Thiocarbonyl Surrogate via Combination of Potassium Sulfide and Chloroform for Dithiocarbamate Construction

Wei Tan, Niklas Jänsch, Tina Öhlmann, Franz-Josef Meyer-Almes* and Xuefeng Jiang*

*University of Applied Sciences Darmstadt, Darmstadt 64295, Germany; East China Normal University, Shanghai 200062, P.R. China, Email:;

W. Tan, N. Jänsch, T. Öhlmann, F.-J. Meyer-Almes, X. Jiang, Org. Lett., 2019, 21, 7484-7488.

DOI: 10.1021/acs.orglett.9b02784

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The combination of potassium sulfide and chloroform provides an efficient and practical thiocarbonyl surrogate. A variety of dithiocarbamates can be synthesized in one-pot reactions in which the thiocarbonyl motif was generated in situ.

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Our group is directing the current research, and Prof. Meyer-Almes helped us to detect the activity of the thiocarbonyl compounds.

Xuefeng Jiang, June 1, 2020

Key Words

dithiocarbamates, multicomponent reactions

ID: J54-Y2019