Palladium-Catalyzed Coupling of Terminal Alkynes with Benzyl Ammonium Salts
Silin Xu, Zhenming Zhang, Chunyu Han, Wenkai Hu, Tiwen Xiao, Yanan Yuan and Junfeng Zhao*
*College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China,
Email: zhaojf
jxnu.edu.cn
S. Xu, Z. Zhang, C. Han, W. Hu, T. Xiao, Y. Yuan, J. Zhao, J. Org. Chem., 2019, 84, 12157-12164.
DOI: 10.1021/acs.joc.9b01877
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Abstract
A highly efficient palladium-catalyzed Sonogashira coupling of benzylic ammonium salts with terminal alkynes provides a series of internal alkyne derivatives in good yields. The reaction offers a broad substrate scope and high functional group tolerance.
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proposed mechanism
Key Words
benzylation, alkynylation, Sonogashira coupling
ID: J42-Y2019
