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Rhenium-Catalyzed Reduction of Carboxylic Acids with Hydrosilanes

Duo Wei, Ruqaya Buhaibeh, Yves Canac and Jean-Baptiste Sortais*

*LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France, Email: jean-baptiste.sortaislcc-toulouse.fr

D. Wei, R. Buhaibeh, Y. Canac, J.-B. Sortais, Org. Lett., 2019, 21, 7713-7716.

DOI: 10.1021/acs.orglett.9b02449 (free Supporting Information)



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Abstract

Re2(CO)10 efficiently catalyzes the direct reduction of various carboxylic acids under UV irradiation at ambient temperature. While aliphatic carboxylic acids were readily converted to the corresponding disilylacetals with low catalyst loading in the presence of Et3SiH, aromatic analogues required more drastic conditions.

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Key Words

reduction of carboxylic acids, silylation, triethylsilane, photochemistry


ID: J54-Y2019