Rhenium-Catalyzed Reduction of Carboxylic Acids with Hydrosilanes

Duo Wei, Ruqaya Buhaibeh, Yves Canac and Jean-Baptiste Sortais*

*LCC-CNRS, Université de Toulouse, CNRS, UPS, Toulouse, France, Email: jean-baptiste.sortaislcc-toulouse.fr

D. Wei, R. Buhaibeh, Y. Canac, J.-B. Sortais, Org. Lett., 2019, 21, 7713-7716.

DOI: 10.1021/acs.orglett.9b02449

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Abstract

Re₂(CO)₁₀ efficiently catalyzes the direct reduction of various carboxylic acids under UV irradiation at ambient temperature. While aliphatic carboxylic acids were readily converted to the corresponding disilylacetals with low catalyst loading in the presence of Et₃SiH, aromatic analogues required more drastic conditions.

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Key Words

reduction of carboxylic acids, silylation, triethylsilane, photochemistry

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ID: J54-Y2019