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Transition-Metal-Free One-Pot Tandem Synthesis of 3-Ketoisoquinolines from Aldehydes and Phenacyl Azides

Budaganaboyina Prasad, Mandalaparthi Phanindrudu, Dharmendra Kumar Tiwari* and Ahmed Kamal*

*Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Raebareli Road, Lucknow 226014; School of Pharmaceutical Education and Research (SPER), Jamia Hamdard, 110 062 New Delhi, India, Email:;

B. Prasad, M. Phanindrudu, D. K. Tiwari, A. Kamal, J. Org. Chem., 2019, 84, 12334-12343.

DOI: 10.1021/acs.joc.9b01534 (free Supporting Information)

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An efficient and transition-metal-free reaction of easily accessible 2-(formylphenyl)acrylates and phenacyl azides provides 3-keto-isoquinolines in very good yields.

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Key Words


ID: J42-Y2019